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I shot a deer with a 22-250 hit it in the heart, the liver exploded into small quarter size pieces. I had custom loaded 70gr speer bullets. It can be done but is really on the small size and not legal in all states. It should be used for what it was intended for varmits. I would start with the 243 and go up from there for deer size game.
 

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onehorse, I agree. We all know the poacher caliber is a 22 long rifle. Small calibers will kill the issue is, is it legal, moral, ethical? Of course not! I too have over 50 deer kills with many different rifle/caliber combinations and believe that the 243 is the starting point for youth/women and go up from there. I think the new 260 rem with a 140 gr bullet is a great rifle for a young hunter to start with.
 
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