i would also think a 300 would cause massive bleading. if you have a place you can shoot it tonight. i would shoot it at a terget. see wich side your off by, or if its up or down, and how far off in that direction it is off. then try to remember the position the deer was in when you took the shot, and use thet to try to estimate were you might have hit it, or if you may not have hit it. might provide some insite that could help you track it, or explane why there was no blood.