I just stepped up from a .243 to a .270. However, any of the calibers you mentioned would work very well for deer. I bought the .243 for my son who was 9 years old at the time. He has done very well with it. I had always muzzle loaded, so when I wanted to try modern rifle I just used my son's .243. It worked great for me. When I purchased one for myself I was torn between the different calibers as well. In the end I went with the .270 and a Redfield scope. Redfield scopes are made in the USA by Leopold and are priced about the same as a Nikon. I'm also a big fan of H&R Handi rifles and Rossi single shot rifles. They are small, light, good quality and very affordable.