I have not shot this caliber. I have reloaded and shot the 25-06, but I personally have not used it for deer. Some feel they lose too much meat from a 25-06 if the deer is closer than 100 yards. A 257 Wby Mag has even a higher velocity than a 25-06. However, I can say the reloads in 25-06 I did for a person performed very well on deer (bucks and does). Several deer have been taken by this person with their 25-06, and all have been one shot kills with some spectacular results.