A 30/06 shooting 165s is about as good as it gets for deer most anywhere. I killed a nice Kentucky buck last year with a Marlin 336ER in .356 Win. Year before I used my M/L, a .50 cal CVA shooting a 295gr Powerbelt over 100gr 777, a CZ 550 FS in 9.3x62 shooting 285gr PP load and a Marlin 1895M (.450) shooting a 350gr JFN Hornady load to take two 8 points and a 7 point. In 2010 I used the same M/L & load, a .44 mag carbine and a Marlin 336 in .375 Win to take a 7 point, 8 point and an 11 point.
I guess it's been a while since I've used one of my '06s, but the '06, like many others, will sure get the job done.