A friend of mine is using a DOA on a .30-06 with no problems at all but he is using the proper one for the .30-06 caliber
which is the DOA 600.
The DOA 250 is only reccomended for a muzzleloader.
I just checked the Bushnell
site to look into it for you.
The following info on the DOA was cut and pasted from Bushnell's website. "Whether you choose a rifle, shotgun, muzzleloader or crossbow to fill your tag,
there is a Dead On Accurate™ (DOA) reticle for you.
Its extended-yardage aiming points enable you to shoot with lethal precision out to
600 yards with a centerfire rifle (DOA 600),
250 yards with a muzzleloader (DOA 250),
200 yards with a shotgun (DOA 200)
or 50 yards with a crossbow (DOA X-Bow)."