A few things are more important than cartridge or caliber.
Knowing your limitations
Knowing the limitations of the cartridge and gun
Bottom line, to each his own. My preference is a 300 WM with a load I develop for the animal I am hunting.
I have seen this question asked in many different forums and it always ended up in an argument. Not here. I like this place!
Very wise words. A good humain kill that does not destroy the meat is all you need. I personaly belive minimum for Deer is .243 I would be worried more about underkill than over kill. Personaly I have taken and droped deer at 200+ yards with my .270. I do however hand load all my ammo and pratice shots longer thatn 200yrs and shoot weekly.