Hi Michael: I agree with the prior comments. I've shot all the rifles you mentioned including the 30-06, which is one of the most versatile of all calibers due to the extreme range of bullet weights available.
I finally got tired of beating up my shoulder at the beginning of each season sighting in on the 200 and 300 yard targets.
I primarily use a 22-250, now. However, you have to have more open ground for shooting (it is not a brush gun) and a heart/neck shot is required if you do not want to injure your animal and/or spend a lot of time trying to track him/her down.
The 22-250 is very high velocity and it has very little drop over 200-250 yards. With a little practice you can drive tacks with it...and it loves my shoulder. Good luck and let us know what you decide on.