#1: If you hunt by yourself, let someone know where you are going and when to expect you back. I leave a map to my general location at my house and one more specific at my truck. On public land this is also helpful because other hunters will know where you are if they hunt the same area.
#2: The first time I hunt a new area, I either stake out a creek or other water source, or look for the biggest, nastiest patch of briars and brush I can find and hunt the very edge of it.
Are you using a climbing stand, portable blind, or are you stalking?