If legal in your state, I see no reason not to, just be sure of the background for bullet travel. A good head shot should be no problem with a scoped 22 at reasonable distances. I watch hunters using 3" mag 12 ga shotguns and doing major damage to the birds and wonder why? I've only killed two turkeys and both were shot with 22 cal rifles. Serious turkey hunters may have a totally different view on this?? This is just my 2 cents worth.